Alpha-2 macroglobulin is a tetrameric glycoprotein MW 725 kDa. Synthesized in the liver, it is a serine proteases inhibitor. It inhibits coagulation by inactivating thrombin and kallikrein, it inhibits fibrinolysis by inactivating plasmin and it is also involved in insulin transport. It is the principal defensin binding protein. It is raised in cirrhosis, pregnancy and diabetes.
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